GMP level anti-human CD28 monoclonal antibody

CD28 is a protein expressed by T cells that provides co-stimulatory signals required for T cell activation and survival. Stimulation of T cells by CD28, in addition to the T cell receptor (TCR), can also provide a potent signal for the production of various interleukins (especially IL-6).

CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. CD80 expression is up-regulated in antigen presenting cells (APCs) upon activation of toll-like receptor ligands. CD86 expression on antigen-presenting cells is constitutive (expression is independent of environmental factors).

CD28 is the only B7 receptor constitutively expressed on Naïve T cells. Association of the TCR of Naïve T cells with the MHC: antigen complex without CD28:B7 interaction results in T cell anemia.

This product is a high-quality mouse monoclonal antibody preparation, including mouse anti-CD28 monoclonal antibody and carrier protein. The antibody recognizes the CD28 molecule, and the anti-CD28 antibody cooperates with the anti-CD3 antibody to stimulate T lymphocytes, and the proportion of CD8+CD25+ cells increases significantly, which can improve the tumor immunity of T cells.

*This product is for research use only.