GMP level anti-human CD16 monoclonal antibody

CD16 is a low-affinity Fc receptor identified as the FcγRIIIa (CD16a) and FcγRIIIb (CD16b) receptors. These receptors bind to the Fc portion of IgG antibodies. CD16 is encoded in specific cell types by two different highly homologous genes. CD16 is present on the surface of natural killer cells, neutrophils, polymorphonuclear leukocytes, monocytes and macrophages. The CD16A antigen is also known as the low affinity immunoglobulin gamma Fc region receptor III-A, FcγRIIIα. CD16B is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, while CD16A is a medium-affinity polypeptide-anchored transmembrane glycoprotein, expressed by natural killer cells(NK), macrophages, T Cell subsets, immature thymocytes and placental growth-promoting cells. CD16A is involved in phagocytosis and enzyme secretion. Inflammatory mediators, antibody-dependent cytotoxicity and immune complex clearance.

When the activation of NK cells is stimulated with anti-CD16 antibody, the zeta chain undergoes tyrosine phosphorylation, resulting in an increase in the concentration of intracytoplasmic Ca2+, an increase in the level of IP3, and the promotion of cytokine synthesis and ADCC.

*This product is for research use only.